PAEDIATRIC MELANOMA

Melanoma is the most common and deadly skin cancer in children and adolescents. However, the biology of paediatric melanoma remains elusive. In our lab, we aim at generating novel models of paediatric melanoma by  combining genetic mouse models, grafting experiments and in vitro cultures. Models that we will use to uncover the biology of those yet unknown paediatric malignancies and to develop new treatments from young patients suffering from this deadly skin cancer.  

MEDULLOBLASTOMA

Medulloblastomas are one of the most common paediatric brain tumours. In our lab, we focus on generating novel models of medulloblastoma and also use the already developed models to uncover the cellular and molecular drivers of medulloblastoma progression and therapy resistance.

NEUROBLASTOMA

Neuroblastomas (NBs) are among  the most common solid tumours and a leading cause of paediatric death. They are composed of different tumour and tumour microenvironment cell populations, and present cellular heterogeneity. Cellular heterogeneity has been proposed to be responsible for tumour progression and therapy resistance. 

We are interested to identify the cell populations that mediate tumour progression in those tumours. In addition, we aim at uncovering how these cell populations dynamically evolve during therapy and infer which populations resist the therapy, potentially leading to tumour relapse. To this end, we combine state-of-the art genetic mouse models, grafting experiments and in vitro cultures.